Stocks closed higher on Wall Street as the market posted its fifth straight gain and the Dow Jones Industrial Average notched another record high. The S&P 500 rose 20.63 points, or 0.3%, to 5,969.34. The benchmark index’s 1.7% gain for the week erased most of its loss from last week and is within about 0.5% of its all-time high set last week. The Dow rose 426.16 points, or 1%, to 44,296.51 as it nudged past its most recent high set last week. The Nasdaq composite rose 42.65 points, or 0.2%, closing at 2,406.67. Markets were volatile the past few weeks, losing ground in the runup to elections in November, then surging following Donald Trump’s presidential victory, before falling again. Several retailers jumped after giving Wall Street encouraging financial updates. Gap soared 12.8% after handily beating analysts’ third-quarter earnings and revenue expectations, while raising its own revenue forecast for the year. Discount retailer Ross Stores rose 2.2% after raising its earnings forecast for the year. EchoStar fell 2.8% after DirecTV called off its purchase of that company’s Dish Network unit. Smaller company stocks had some of the biggest gains. The Russell 2000 index rose 1.8%. A majority of stocks in the S&P 500 gained ground, but those gains were kept in check by slumps for several big technology companies. Nvidia fell 3.2%. Its pricey valuation makes it among the heaviest influences on whether the broader market gains or loses ground. The company grew to a nearly $3.6 trillion behemoth because of demand for its chips used in artificial-intelligence technology. Intuit, which makes TurboTax and other accounting software, fell 5.7%. Its quarterly earnings forecast fell short of analysts’ expectations. Facebook owner Meta Platforms fell 0.7% after the Supreme Court allowed a multibillion-dollar class-action investors’ lawsuit to proceed against the company. It stems from the privacy scandal involving the Cambridge Analytica political consulting firm. European markets closed mostly higher and Asian markets ended mixed. Crude oil prices rose. Treasury yields held relatively steady in the bond market. The yield on the 10-year Treasury fell to 4.41% from 4.42% late Thursday. In the crypto market, bitcoin hovered around $99,000, according to CoinDesk. It more than doubled this year and first surpassed the $99,000 level Thursday. Retailers remained a big focus for investors this week amid close scrutiny on consumer spending habits headed into the holiday shopping season. Walmart, the largest U.S. retailer, reported a quarter of strong sales and gave an encouraging financial forecast. Target, though, reported weaker earnings than analysts’ expected. Get local news delivered to your inbox!Michigan rolls to 112-64 victory over Western KentuckyNew Orleans (4-8) at New York Giants (2-10) Sunday, 1 p.m. EST, Fox BetMGM NFL Odds: Saints by 5. Against the spread: Saints 5-7; Giants 3-9. Series record: Giants lead 17-15. Last meeting: Saints beat Giants 24-6 on Dec. 17, 2023, in New Orleans. Last week: Saints lost to Rams 21-14; Giants lost to Cowboys 27-20. Saints: overall (12), rush (10), pass (19), scoring (14) Saints defense: overall (30), rush (26), pass (29), scoring (19) Giants offense: overall (T26), rush (15), pass (31), scoring (32) Giants defense: overall (19), rush (29), pass (6), scoring (18) Turnover differential: Saints plus-2; Giants minus-8. Derek Carr. The quarterback completed 23 of 28 for 218 yards, three touchdowns, and no interceptions in the previous meeting and had a 134.8 quarterback rating. Drew Lock. The veteran quarterback is going to make his second straight start with Tommy DeVito (forearm) hurt. He threw for 178 yards and ran for a career-high 57 yards in the loss to the Dallas. He scored on an 8-yard run and had a 28-yard scramble to set up another. He also made mistakes, throwing a pick-6 and losing a fumble on a scramble. Saints offense vs Giants defense. The Giants defense is banged up. DT Dexter Lawrence (elbow) was put on injured reserve Monday and fellow starter Rakeem Nunez-Roches (neck) missed practice earlier in the week. Leading tackler and ILB Bobby Okereke is dealing with a back issue. Saints: Tight end Taysom Hill's knee injury last week will sideline him the rest of the season. Running back Kendre Miller (hamstring) is eligible to come off injured reserve and could return to the lineup Sunday. Guards Cesar Ruiz (concussion) and Nick Saldiveri (knee) have been held out of practice this week. Center Erik McCoy (groin) , who sat out last week's game, returned to practice early this week on a limited basis. Guard Lucas Patrick (calf) has practiced on a limited basis after sitting out the past three games. Tyrann Mathieu (forearm) has returned to full practice this week after sitting out much of the second half of last week's loss to the Los Angeles Rams. Giants: Lawrence and rookie TE Theo Johnson (foot) were placed on injured reserve and probably are out for the season. ... DeVito (forearm) and LT Jermaine Eluemunor (quad) missed the Dallas game but they are making progress this week. DeVito will back up Lock. ... Eluemunor and RT Evan Neal (hip) may be game-time decisions. ... CB Deonte Banks (ribs), Okereke (back) and Nunez-Roches (neck) are unlikely to play. WR Malik Nabers was added to the report Thursday with a nagging groin issue. The Saints have won two of the past three meetings. The Giants are winless in all six games at MetLife Stadium this season. The Saints are 2-1 under interim coach Darren Rizzi, who was born in New Jersey and grew up a Giants fan. ... Carr ranks sixth among qualified passers with a 103.3 rating in 2024. ... WR Marquez Valdes-Scantling has had TD catches in his past three games. ... TE Juwan Johnson had five catches against the Rams. ... DT Bryan Bresee has a career-high 6 1/2 sacks and is looking for his third straight game with a sack. He had two sacks against New York last season. ... DL Chase Young has two sacks and three tackles for loss against the Giants in December. ... LB Demario Davis had 10 tackles and a sack in the previous meeting. ... CB Alontae Taylor is the only player with at least 10 passes defended and five tackles for loss in each of the past two seasons. ... Mathieu needs five tackles for his eighth straight season of at least 50 tackles. ... Giants: RB Tyrone Tracy ranks second among rookies with 619 yards rushing. He has run for four touchdowns. ... WR Malik Nabers has 75 catches for 740 yards. His reception total is the most by a rookie in his first 10 games. .... Wan'Dale Robinson has career-high 63 catches. ... OLB Brian Burns has a career-high eight passes defended and 10 tackles for loss. ... Okereke needs seven tackles for his fourth straight season of 100 or more tackles. ... S Tyler Nubin leads all rookies and ranks fourth among DBs with 93 tackles. ... The Giants have set an NFL record going 11 straight games without an interception. They have one interception this season. The NFL record for fewest in a season is two by the 2018 San Francisco 49ers. The fewest in a season by the Giants was six in 2022. Look for running back Alvin Kamara to have a big game. He has 894 yards rushing on 206 carries and he has caught 59 passes for 450 yards. He has seven touchdowns, six rushing. The 29-year-old has had eight games of at least 100 yards from scrimmage this season and he is third in the league with 1,344 yards from scrimmage. AP NFL: https://apnews.com/hub/nflStock market today: Rising tech stocks pull Wall Street to another record
OSAKA, Japan and MONTREAL , Dec. 5, 2024 /PRNewswire/ -- Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan ; President: Toichi Takino; "Ono") announced that it has entered into a drug discovery collaboration agreement with Congruence Therapeutics (Headquarters: Montreal, Quebec, Canada ; CEO: Clarissa Desjardins; "Congruence") to generate novel small molecule correctors against multiple protein targets in the oncology area by leveraging Congruence's proprietary drug discovery platform, RevenirTM. Under the terms of the agreement, Congruence will generate small molecule correctors by leveraging Congruence's proprietary drug discovery engine called, RevenirTM. Ono will obtain an exclusive option right to develop, manufacture and commercialize the identified small molecule correctors worldwide. Congruence will be eligible to receive an upfront payment, research expenses, milestone payments based on research and development progress and sales, as well as tiered royalties based on net sales. "We believe that this collaboration with Congruence may help generating novel small molecule correctors for validated targets in the oncology area by leveraging their own technologies in protein dynamics and computational biology, leading to our development pipeline," said Seishi Katsumata , Corporate Officer / Executive Director, Discovery & Research of Ono. "We will be committed to delivering innovative new drugs to cancer patients as soon as possible." "Congruence is thrilled to partner with Ono, which has established itself as a global leader in drug development, particularly in the oncology space. We believe that our RevenirTM platform and capabilities in protein dynamics will accelerate the discovery of novel therapies for compelling targets of interest to both companies," said Sharath Hegde PhD, Chief Scientific Officer of Congruence. About RevenirTM Drug Discovery Platform RevenirTM, Congruence's proprietary computational drug discovery platform, captures the dynamic biophysical changes caused by mutations in proteins, offering unique insights into protein defects and their correction. By examining surface features and a spectrum of biophysical descriptors across an ensemble of protein conformers, RevenirTM predicts small molecule induced correction of the underlying defect. About Congruence Therapeutics Congruence is a computationally-driven biotechnology company building a unique pipeline of transformative small molecule correctors rationally designed to rescue aberrant protein function. Congruence's proprietary scalable platform, RevenirTM, captures the biophysical features of proteins across their conformational ensembles, in order to identify novel allosteric and cryptic pockets which are virtually screened to generate novel chemical matter. For more information, please visit www.congruencetx.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/ono-enters-into-drug-discovery-collaboration-agreement-with-congruence-therapeutics-to-generate-novel-small-molecule-correctors-in-the-oncology-area-302324452.html SOURCE Ono Pharmaceutical co., ltd.Article content The NDP’s efforts to improve health care through a new payment model for family physicians and the establishment of urgent and primary care centres has had the unintended consequence of cutting the ranks of walk-in clinics across the province. According to the medical mapping service MediMap, the number of walk-in clinics across B.C. has dropped between 30 to 50 per cent in recent years as clinics move to an appointment-only model or close their doors. This has led some doctors to warn that there are fewer and fewer options for immediate care in the province as urgent-care-clinic appointments remain hard to book in certain communities and emergency room waiting times continue to skyrocket. Rita McCracken, a family physician and UBC assistant professor in the family practice department, said part of the problem is the new payment model introduced by then-health minister Adrian Dix in 2023 that aims to retain family physicians through better compensation. The model encourages doctors to work in family practice instead of putting in hours at a walk-in clinic, she said. She likened health care to the education system and wants the province to increase the capacity of primary care, arguing that neither walk-in clinics nor urgent and primary care centres are an ideal model. “If we want people to have better access to primary care when they need it, we need to have clinics that have the capacity to be able to provide care to the people that live close by, just like we do for elementary schools,” McCracken said. “I’m not saying that there aren’t many, many problems with education right now, but if we just kind of take a look at that model of access to public education, we’ve completely thrown that out the window when it comes to primary care.” She said there needs to be a wholesale rethinking of how primary care is provided to people without a family doctor and that interested parties such as municipalities and community groups need to come together to figure out a solution. Some physicians say they have seen first-hand the effects of the decline of walk-in clinics. Kevin Mcleod, a North Vancouver-based internal medicine specialist, says people now come to see him for basic ailments, such as a bladder infection, that would be better dealt with by a general physician. “They don’t need to see me as a specialist, but they have nowhere else to go.” Mcleod said a walk-in clinic across the street from his office has papered over a sign saying “no appointment necessary,” indicating it has moved to an appointment-only model. The company that owns the clinic, Well Health Technologies Corp., did not respond to a request for comment, but a representative of the North Vancouver clinic said it does still accept non-registered patients, those patients now need to make an appointment. “I know the government gives their statistics that thousands of people are getting attached to a family doctor, but there’s still 800,000 people who aren’t and where do they go?” asked McLeod. “A lot of people don’t realize (that) if your family doctor retires or deactivates their college number, any outstanding refills or renewals of medications that you might have at your pharmacy are all automatically cancelled.” Josie Osborne, B.C.’s new health minister, told Postmedia she is aware of the challenges in getting primary care. Osborne says the main challenge is the shortage of health-care professionals in B.C. and believes the province’s efforts to recruit more physicians, nurse practitioners and other health workers fields will help. As for treading the line between encouraging doctors to go into family practice and working at a walk-in clinic, the minister said it will be a matter of working with family doctors and health-care professionals in each community. “The nature of the way primary care is being delivered is changing, and we’re seeing that in what physicians want, in terms of their work life, their work style, but also in needing to stand up clinics that work for communities and being able to tailor them well for what a community’s needs are,” said Osborne. MediMap CEO Thomas Jankowski said solutions are needed in short order as the closures of clinics has made waiting times at remaining walk-in clinics rise by 60 per cent. Meanwhile, emergency room waiting times continue to worsen as more people lose access to other options for primary care. According to the provincial government’s website, all or most of the walk-in clinics in communities like Victoria, Surrey, Langley and Maple Ridge are by appointment only. Nanaimo only has one walk-in clinic. “Wait times at ERs are getting horrific right now, and this might be actually the first year that we’ll talk about ER waiting times more openly as we’re starting to monitor those across the country as well. We’re seeing now the first year in which it’s quite regular to see entire ERs close because of staffing issues because of doctor burnout,” said Jankowski. “I just feel that health care is very much in a free fall right now, and we’re not really thinking of systemic solutions in a way that truly address this, as opposed to moving the puck from one place to another, which isn’t working.”As one of the world's premier superstar athletes, LeBron James often finds himself on the receiving end of criticism over his views on basketball, life, and the world of politics. MMA star Colby Covington became the most recent public figure to call him out and even went viral for calling James a "f***ing scumbag." “I wanna ask LeBron, what does he mean by ‘There’s no party like a Diddy party’? Not only that, but I wanna ask how many Diddy parties he's been to," said Covington on media day . "LeBron you’re a f***ing scumbag and I hope you get locked up in the same cell with Diddy." LeBron James has managed to avoid any serious controversies after 21 years in the NBA but his political views often incite anger in some of his biggest critics -- even if it wasn't meant to be controversial. In the case of Colby Covington, he's been a longtime hater of LeBron James and has gone to great lengths to try and smear his legacy. In the past, Colby has called LeBron a coward, a communist, and even a " Chinese finger puppet ." He's been vocal about his hatred for the King and about how he uses tricks to enhance his reputation. In this latest quote, Colby is seemingly exposing LeBron for his apparent (and unconfirmed) connection to Diddy, who was recently arrested on sex trafficking charges. Diddy's infamous parties have become legendary in the community and anyone associated with them has been branded as partially complicit in his behavior. LeBron doesn't have any personal connection to Diddy but he may have admitted to going to one of his parties in a resurfaced video that has gone viral online. Seemingly, many stars have attended the "Diddy" parties over the years, which may or may not have included illegal sex acts. If James were ever caught participating in something like that, his entire reputation would essentially be shot and the image he's worked so hard to build over the past 20 years will almost immediately be washed away. Fortunately for James, that comment is the only connection he has to Diddy but it's still enough for some (like Colby Covington) to use it against LeBron's legacy. As arguably LeBron's biggest hater, this won't be the last we hear from Covington on this subject but he shouldn't expect to get any response from LeBron. At this stage of his career, James has accomplished far too much to let one man's petty hatred get under his skin. Instead, this season, LeBron is keeping his head down and taking care of business one game at a time. For those he can't win over with his superior work ethic, he'll win over with his sheer dominance on the court. But James doesn't really care either way because the only validation he needs is from himself. With averages of 23.0 points, 9.1 assists, and 8.0 rebounds per game this season, LeBron is defying Father Time with every game and he's setting a new standard for individual greatness in the modern era. In the meantime, he's also giving back to his community, supporting his family by helping them achieve their dreams and growing his empire in business and entertainment. At this point, it's no wonder why LeBron is unphased by all the hate and why he lets people like Colby Covington go off on his name with no response. This article first appeared on Fadeaway World and was syndicated with permission.
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DUP ministers Peter Robinson and Nigel Dodds were sanctioned in 2000 by Stormont’s leaders over their plan to disrupt the powersharing Executive. Minutes of an Executive meeting from June of that year state further action would be considered “as appropriate” if the DUP went ahead with a threat to rotate its ministers. The minutes are within files which have been declassified at the Public Record Office in Belfast. Devolved powersharing had been restored to Northern Ireland in May 2000 when Ulster Unionist leader David Trimble had received the backing of his party to go back into the Assembly, despite there having been no decommissioning of IRA arms at that point. The party also said it would rotate its ministerial posts to prevent other parties from taking them. A minute of an Executive meeting on June 8 said Mr Robinson and Mr Dodds had refused a request from First Minister Mr Trimble and deputy First Minister Seamus Mallon to meet with them “to discuss recent public comments by the DUP concerning their positions as ministers”. The minute records that the Executive endorsed a proposal from the First and deputy First Ministers to write again to the two DUP ministers setting out sanctions against them. “The Minister for Social Development and the Minister for Regional Development would not be nominated to attend meetings of the Joint Ministerial Committee. “Pending the receipt of satisfactory assurances from DUP Ministers regarding the confidentiality and integrity of Executive Committee business, the Minister for Social Development and Minister for Regional Development would not receive Executive Committee papers as of right. “The First Minister and Deputy First Minister would seek briefing, as appropriate, from officials in the Department for Regional Development and Department for Social Development.” The minute continues: “If the DUP carried out their threat to change the holders of the two Ministerial offices on a frequent basis, the Executive Committee would consider other action as appropriate.” Mr Robinson and Mr Dodds resigned as ministers on June 27 and were replaced by party colleagues Gregory Campbell and Maurice Morrow. A minute from an Executive meeting that day says: “The Executive Committee noted that the Minister for Social Development and Minister for Regional Development would be resigning their posts that afternoon, and expressed concern at the proposed rotation of the ministries held by their Party Members.”
DUP minister rejected suggestion licensing laws could be relaxed for jubileeVAUGHAN, ON , Dec. 11, 2024 /CNW/ - Menkes Developments Ltd. ("Menkes"), and QuadReal Property Group ("QuadReal") are pleased to announce the successful "topping off" of Festival, a four-tower community in the heart of south Vaughan Metropolitan Centre ("VMC"). Festival is already an architectural landmark on the Vaughan skyline with its distinctive sculptural white balconies and its tallest tower standing at 190.5 meters, making it the tallest building in all of VMC. The "topping off" is a major milestone in the construction progress, signifying the completion of the entire community's exterior structural framework. Festival broke ground in early 2021 and was named Canada's Best-Selling Condominium Community for two consecutive years in 2020 and 2021. The development sits on a 5.5-acre property bounded on the north and south by Highways 7 and 407, and Hwy 400 to the west. Festival is a significant project boasting 2,470 residential units across 4 towers ranging in height from 41 to 59 storeys, 70,000 square feet of state-of-the-art indoor amenities, 85,000 square feet of commercial space, ample public open spaces, and a covered pedestrian mews connecting residents and visitors to future phases of the masterplan. The overall value of Festival is $1.5 billion dollars . "As one of the fastest growing cities in Canada , the City of Vaughan is committed to delivering more housing options for our residents and future generations. I am proud to mark this historic milestone for Festival where families can soon call the Vaughan Metropolitan Centre home,", said Steven Del Duca , Mayor of Vaughan . "I want to thank Menkes Developments Ltd. and QuadReal Property Group for their dedication and support in getting more homes built in the city of Vaughan . By working together, we will help make housing more affordable for young families." "Festival is like no other project in the GTA – it's an ambitious, all-encompassing community that sets a new industry standard in Vaughan . We brought the urban lifestyle that we deliver in our large mixed-use projects like Harbour Plaza in the South Core and Sugar Wharf on Toronto's Waterfront to the VMC," said Jared Menkes , Executive Vice President of High Rise Residential, Menkes. "We worked collaboratively with the City of Vaughan's political leaders and planning staff to develop Festival to meet the needs of residents in one of Canada's fastest growing cities. Festival is a testament to all that can be accomplished when we work together." The first tower at Festival began welcoming residents earlier this year, with occupancies expected to continue for all towers through to Fall 2025. Festival will eventually be home to over 5,000 residents. "The creation of both Festival and the broader Assembly Park community has been a collaborative and thoughtful process, and we are thrilled to officially top off this dynamic part of the new Vaughan Metropolitan Centre," said Toby Wu , Executive Vice President, Development, Canada , QuadReal. "Leveraging a long-term approach to investment and development enables us to build thriving communities in markets where people want to live. Thank you to the QuadReal team and our partners at Menkes and the City of Vaughan for helping us bring our vision to life." Menkes and QuadReal have been the most active developers in VMC since 2019, with over 5,200 residential units built, under construction, and pre-selling. The partners recently completed Mobilio, VMC's first mixed-density residential community with three mid-rise condominium towers (750 units), 400 townhouses, park space and amenities all in one site. Following the success of the four Festival towers that are now commencing occupancies, last year Menkes and QuadReal launched the next phase of the masterplan known as Bravo – a three-tower community directly south of Festival. Bravo will feature 1,654 residential units, at grade retail, the continuation of the covered pedestrian mews, and a privately-owned public park space. The first two towers – East and West – at Bravo are currently 80% sold after being one of the GTA's best-selling communities in 2023. Construction for the first tower began in Spring 2024. The third and final tower in the project, the South Tower also known as Encore, is selling now with a model suite available for viewing at the Festival Discovery Centre. For more information, visit festivalsouthvmc.com . Leasing of the retail space of Festival has begun and inquiries can be directed to assemblypark.com . About Menkes Developments Ltd. Menkes Developments Ltd. is an award-winning, fully integrated real estate company involved in the construction, ownership and management of office, industrial, retail and residential properties. Founded in 1954, the company is one of the largest private developers in Canada , with a primary focus in the Greater Toronto Area . Menkes is known for its innovative, multi-disciplinary approach, superior design, and its expertise in large-scale mixed-used developments. The Company is regarded as one of the most trusted builders in Toronto , with a strong reputation for quality and customer service excellence. Past projects include the Four Seasons Hotel & Residences in Bloor-Yorkville, 25 York Street (Telus Harbour), and the two million square foot Harbour Plaza/One York commercial retail complex located in the South Core Financial District. For more information about Menkes, visit menkes.com and follow @MenkesLife . About QuadReal Property Group and BCI QuadReal Realty QuadReal Property Group is a global real estate investment, operating and development company headquartered in Vancouver, British Columbia . Its assets under management are $85 billion . From its foundation in Canada as a full-service real estate operating company, QuadReal has expanded its capabilities to invest in equity and debt in both the public and private markets. QuadReal invests directly, via programmatic partnerships and through operating platforms in which it holds an ownership interest. QuadReal seeks to deliver strong investment returns while creating sustainable environments that bring value to the people and communities it serves. Now and for generations to come. QuadReal: Excellence lives here. www.quadreal.com Media Contact: Menkes Danny Roth – droth@brandoncom.ca Media Contact: QuadReal Hannah Wanlin – hannah.wanlin@quadreal.com SOURCE Menkes Developments Ltd. View original content to download multimedia: http://www.newswire.ca/en/releases/archive/December2024/11/c7635.html © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
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